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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/10121

Title: Mechanism of antiplatelet action of hypolipidemic, antidiabetic and antihypertensive drugs by PPAR activation PPAR agonists: New antiplatelet agents
Authors: Fuentes, E.
Palomo, I.
Keywords: proliferator-activated receptors
Antihypertensive peroxisome
Issue Date: Sep-2014
Citation: VASCULAR PHARMACOLOGY 62 (3) : 162-166
Abstract: Given the prevalence of cardiovascular disease in patients with cardiovascular risk factors (i.e., hypertension, diabetes, smoking and obesity) and that platelet activation plays an important pathogenic role in cardiovascular diseases, it is very important to identify the drugs that have multiple targets. In this sense, the present article describes the mechanism of antiplatelet action of hypolipidemic (statins and fibrates), antidiabetic (thiazolidinediones) and antihypertensive (nifedipine) drugs via peroxisome proliferator-activated receptor (PPAR) activation. The mechanism of antiplatelet action of the drugs is by direct activation of PPARs with the inhibition of cyclooxygenase-1, protein kinase C-alpha, calcium mobilization, thromboxane A2, sCD40L, platelet microparticles and cAMP-phosphodiesterase, and the stimulation of proteins kinase G and A Thus, these observations highlight PPARs as a novel therapeutic target for the treatment and prevention of cardiovascular diseases. (C) 2014 Elsevier Inc. All rights reserved.
Description: Univ Talca, Fac Hlth Sci, Dept Clin Biochem & Immunohaematol, Interdisciplinary Excellence Res Program Hlth Agi, Talca, Chile. Fuentes, E (Fuentes, Eduardo); Palomo, I (Palomo, Ivan)
URI: http://dspace.utalca.cl/handle/1950/10121
ISSN: 1879-3649
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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