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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/10140

Title: Synthesis and in vitro antiproliferative evaluation of 3-acyl-2-arylamino-1,4-naphthoquinones
Authors: Rios, D.
Benites, J.
Torrejon, F.
Theoduloz, C.
Valderrama, JA.
Keywords: Antiproliferative activity
Half-wave potential
Donor-acceptor compounds
Issue Date: Sep-2014
Citation: MEDICINAL CHEMISTRY RESEARCH 23 (9) : 4149-4155
Abstract: A variety of 3-acyl-2-arylamino-1,4-naphthoquinones were synthesized and evaluated for their antiproliferative activities on a panel of three cancer cells. The designed compounds were prepared from their respective acylhydroquinones by oxidation with silver (I) oxide, followed by amination of the resulting 2-acyl-1,4-naphthoquinones, under aerobic conditions. The donor-acceptor properties of the 2,3-disubstituted 1,4-naphthoquinones were evaluated by means of their first half-wave potentials. The biological screening of the 1,4-quinones showed that the antiproliferative activity depends upon the nature of the substituents at the quinone nucleus. The effect of the substituents on the antiproliferative activity is discussed in terms of their donor-acceptor interactions and lipophilicity.
Description: Univ Talca, Fac Ciencias Salud, Talca, Chile. Theoduloz, C (Theoduloz, Cristina)
URI: http://dspace.utalca.cl/handle/1950/10140
ISSN: 1554-8120
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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