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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/10161

Title: Regulatory mechanisms of cAMP levels as a multiple target for antiplatelet activity and less bleeding risk
Authors: Fuentes, E.
Palomo, I.
Keywords: Antiplatelet
Bleeding risk
Issue Date: Aug-2014
Citation: THROMBOSIS RESEARCH 134 (2): 221-226
Abstract: Platelet activation is a critical component of atherothrombosis. The multiple pathways of platelet activation limit the effect of specific receptor/pathway inhibitors, resulting in limited clinical efficacy. Recent research has confirmed that combination therapy results in enhanced antithrombotic efficacy without increasing bleeding risk. In this way, the best-known inhibitor and turn off signaling in platelet activation is cAMP. In this article we discuss the mechanisms of regulation of intraplatelet cAMP levels, a) platelet-dependent pathway: Gi/Gs protein-coupled receptors, phosphodiesterase inhibition and activation of PPARs and b) platelet-independent pathway: inhibition of adenosine uptake by erythrocytes. With respect to the association between intraplatelet cAMP levels and bleeding risk it is possible to establish that compounds/drugswith pleitropic effect for increased intraplatelet cAMP level could have an antithrombotic activity with less risk of bleeding. (C) 2014 Elsevier Ltd. All rights reserved.
Description: Univ Talca, Fac Hlth Sci, Dept Clin Biochem & Immunohaematol, Interdisciplinary Excellence Res Program Healthy, Talca, Chile. Fuentes, E (Fuentes, Eduardo); Palomo, I (Palomo, Ivan)
URI: http://dspace.utalca.cl/handle/1950/10161
ISSN: 0049-3848
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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