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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/1547

Title: Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors
Authors: Bianchi, D.A.
Schmeda-Hirschmann, G.
Theoduloz, C.
Bracca, A.B.J.
Kaufman, T.S.
Keywords: acetylcholinesterase inhibitors
oxazaphenalenes
stephaoxocanes
isoquinoline alkaloids
Issue Date: 2-Jun-2005
Publisher: Pergamon-Elsevier Science Ltd.
Citation: Bioorganic & Medicinal Chemistry Letters 15 (11): 2711-2715
Abstract: The synthesis of simplified analogs of the novel isoquinoline alkaloid stephaoxocanidine, carrying the oxazaphenalene ABC-ring system of the natural product, and their activity as inhibitors of the enzyme acetylcholinesterase, are reported. 5,6-Dimethoxy-7H-8-oxa-1-aza-phenalen-9-one (5) was as active as a Narcissus extract enriched in galantamine.
Description: Schmeda-Hirschmann, G. Laboratorio de Quımica de Productos Naturales, Instituto de Quımica de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile.
Theoduloz C. Facultad de Ciencias de la Salud, Laboratorio de Cultivo Celular, Universidad de Talca, Casilla 747, Talca, Chile
URI: http://dspace.utalca.cl/handle/1950/1547
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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