Synthesis of some secondary amine derivatives bearing a heteroaryl fragment

Abstract

Diverse N-(heteroarylmethyl)anilines were easily prepared from corresponding aldimines derived from commercially available aromatic aldehydes and anilines. New series of substituted NH-tetrahydroquinolines were also prepared using imino-Diels-Alder reaction between aldimines and N-vinylpyrrolidin-2-one in the presence of (BF3OEt2)-O-. and the multi-component condensation reactions using a friendly ecological catalyst(BiCl3). The secondary amines obtained bearing a heteroaryl moiety were tested as possible antibacterial and antifungal agents.