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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/1670

Title: Free radical scavengers and antioxidants from Baccharis grisebachii
Authors: Tapia, A.
Rodriguez, J.
Theoduloz, C.
Lopez, S.
Feresin, G.E.
Schmeda-Hirschmann, G.
Keywords: Baccharis grisebachii
Asteraceae
p-coumaric acid derivatives
flavonoids
labdane diterpenes
antioxidants
Issue Date: Dec-2004
Publisher: Elsevier Science Ireland Ltd.
Citation: Journal of Ethnopharmacology 95 (2-3): 155-161
Abstract: The exudate and seriated extracts from the aerial parts of Baccharis grisebachii (Asteraceae) which is recommended as a digestive and to relieve gastric ulcers in Argentina, showed activity as free radical scavengers and inhibited lipoperoxidation in erythrocytes. Assay-guided isolation led to seven p-coumaric acid derivatives and six flavonoids as the main active constituents of the crude drug. The activity towards the superoxide anion was mainly due to the flavonoid constituents. 5,7,4'-Trihydroxy-6-methoxyflavone and quercetin presented high activity (64 and 79%) even at 12.5 mug/ml. The xanthine oxidase inhibitory effect of the extracts can be related with the p-coumaric acid derivatives drupanin, 4-acetyl-3,5-diprenylcinnamic acid and trans-ferulic acid O-hexan-3-onyl-ether which showed IC50 values in the range 28-40 mug/ml. Both p-coumaric acid derivatives and flavonoids inhibited lipoperoxidation in erythrocytes. The highest activity was found for the p-coumaric acid derivatives 4-acetyl-3-prenyl-ethoxycinnamate, 3-prenyl-4-(4'-hydroxydihydrocinnamoyloxy)-cinnamate and trans-ferulic acid O-hexan-3-onyI-ether (69-82%) and the flavonoids 5,7,4'-trihydroxy-6-methoxyflavone, quercetin, 5,7,4'-trihydroxy-6,3'-dimethoxyflavone and 5,7,4'-trihydroxy-6,8-dimethoxyflavone (64-84%) at 100 mug/ml.
Description: Schmeda-Hirschmann, G, (reprint author) and Tapia A. Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile.
Rodriguez, J. and Theoduloz, C. Departamento de Ciencias Básicas Biomédicas, Facultad de Ciencias de la Salud, Universidad de Talca, Casilla 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/1670
ISSN: 0378-8741
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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