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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/3336

Title: In vitro antibacterial activity of the peptide PsVP-10 against antimicrobial-resistant Enterococcus faecalis isolated from clinical samples
Authors: Padilla, C.
Lobos, O.
Brevis, P.
Abaca, P.
Hubert, E.
Keywords: antibiotics; multiresistance and human infections
Issue Date: Feb-2004
Publisher: Oxford University Press
Citation: Journal of Antimicrobial Chemotherapy 53 (2): 390-392
Abstract: Objective: To analyse the antimicrobial activity of the peptide PsVP-10 against 67 resistant Enterococcus faecalis strains isolated from clinical samples. Methods: The qualitative disc diffusion method and MIC determinations were used. Results: The presence of several multidrug-resistant phenotypes of E. faecalis was demonstrated, in which there were high MICs to chloramphenicol, tetracycline, vancomycin, cefaloridine, ampicillin and gentamicin. In comparison, the peptide PsVP-10 showed lower MICs against all the multidrug-resistant and susceptible E. faecalis. Conclusions: There is an urgent need for the development of novel antimicrobial agents against the highly resistant E. faecalis. The present study shows that the peptide PsVP-10 might make a contribution to the solution of this serious problem.
Description: Padilla, C. (reprint author), 2 Norte 685, Talca, Chile.Univ Talca, Lab Invest Microbiol, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/3336
ISSN: 0305-7453
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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