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|Title: ||In vitro antibacterial activity of the peptide PsVP-10 against antimicrobial-resistant Enterococcus faecalis isolated from clinical samples|
|Authors: ||Padilla, C.|
|Keywords: ||antibiotics; multiresistance and human infections|
|Issue Date: ||Feb-2004 |
|Publisher: ||Oxford University Press|
|Citation: ||Journal of Antimicrobial Chemotherapy 53 (2): 390-392|
|Abstract: ||Objective: To analyse the antimicrobial activity of the peptide PsVP-10 against 67 resistant Enterococcus faecalis strains isolated from clinical samples.
Methods: The qualitative disc diffusion method and MIC determinations were used.
Results: The presence of several multidrug-resistant phenotypes of E. faecalis was demonstrated, in which there were high MICs to chloramphenicol, tetracycline, vancomycin, cefaloridine, ampicillin and gentamicin. In comparison, the peptide PsVP-10 showed lower MICs against all the multidrug-resistant and susceptible E. faecalis.
Conclusions: There is an urgent need for the development of novel antimicrobial agents against the highly resistant E. faecalis. The present study shows that the peptide PsVP-10 might make a contribution to the solution of this serious problem.|
|Description: ||Padilla, C. (reprint author), 2 Norte 685, Talca, Chile.Univ Talca, Lab Invest Microbiol, Talca, Chile.|
|Appears in Collections:||Artículos en publicaciones ISI - Universidad de Talca|
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