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| Title: | In vitro antibacterial activity of the peptide PsVP-10 against antimicrobial-resistant Enterococcus faecalis isolated from clinical samples |
| Authors: | Padilla, C.
Lobos, O.
Brevis, P.
Abaca, P.
Hubert, E. |
| Keywords: | antibiotics; multiresistance and human infections |
| Issue Date: | Feb-2004 |
| Publisher: | Oxford University Press |
| Citation: | Journal of Antimicrobial Chemotherapy 53 (2): 390-392 |
| Abstract: | Objective: To analyse the antimicrobial activity of the peptide PsVP-10 against 67 resistant Enterococcus faecalis strains isolated from clinical samples.
Methods: The qualitative disc diffusion method and MIC determinations were used.
Results: The presence of several multidrug-resistant phenotypes of E. faecalis was demonstrated, in which there were high MICs to chloramphenicol, tetracycline, vancomycin, cefaloridine, ampicillin and gentamicin. In comparison, the peptide PsVP-10 showed lower MICs against all the multidrug-resistant and susceptible E. faecalis.
Conclusions: There is an urgent need for the development of novel antimicrobial agents against the highly resistant E. faecalis. The present study shows that the peptide PsVP-10 might make a contribution to the solution of this serious problem. |
| Description: | Padilla, C. (reprint author), 2 Norte 685, Talca, Chile.Univ Talca, Lab Invest Microbiol, Talca, Chile. |
| URI: | http://dspace.utalca.cl/handle/1950/3336 |
| ISSN: | 0305-7453 |
| Appears in Collections: | Artículos en publicaciones ISI - Universidad de Talca
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