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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/3342

Title: Anti phospholipid antibodies in Chilean patients with systemic lupus erythematosus
Authors: Palomo, I.
Pereira, J.
Alarcon, M.
Larrain, A.M.
Pinochet, C.
Vasquez, M.
Velez, M.T.
Leon, M.
Espinola, R.
Pierangeli, S.
Issue Date: Nov-2002
Publisher: Mosby Inc.
Citation: Journal of Laboratory and Clinical Medicine 40 (5): 336-341
Abstract: ntiphospholipid antibodies (aPLs) are a heterogeneous family of antibodies found in autoimmune disorders, infectious diseases, and other situations. The presence of different aPLs has been associated with various clinical manifestations of the antiphospholipid syndrome (APS). The objective of this study was to investigate the prevalence of aPLs in a group of 90 Chilean patients with systemic lupus erytematosus (SLE) and 90 healthy controls. We measured anticardiolipin antibodies (aCLs), antiphosphatidylserine antibodies (aPSs), anti-beta(2) glycoprotein I antibodies (anti-beta(2)GPIs), and antiprothrombin antibodies (aPTs) with an enzyme-linked immunosorbent technique using "in-house" assays. Fifty-four of 90 SLE patients (60.0%) had some type of aPL. Forty of 90 (44.4%) were positive for aCLs, 9 of 61 (14.8%) had aPSs, 21 of 90 (23.3%) had anti-beta(2)GPIs, and 18 of 90 (20.0%) had aPTs. In the control group, prevalences were as follows: aCLs, 3.3%; aPSs, 1.1%; anti-beta2GPIs, 1.1%; aPTs, 2.2%. In most cases, values were in the low-positive range. Of all aPL detected, 29.5% was of the IgG isotype, 37.5% IgM, and 33.0% IgA. We observed a correlation between aCLs and aPSs and of these antibodies with anti-beta(2)GPIs and aPTs but not between anti-beta2GPIs and aPTs. Our results show a high prevalence of aPLs in SLE patients. An association between different specificities and isotypes of aPLs was also observed.
Description: Palomo, I.G.; Vasquez, M.R. y Alarcon, M.L. Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Universidad de Talca, Casilla N° 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/3342
ISSN: 0022-2143
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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