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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/3343

Title: Patients with essential hypertension present higher levels of sE-selectin and sVCAM-1 than normotensive volunteers
Authors: Palomo, I.
Marin, P.
Alarcon, M.
Gubelin, G.
Vinambre, X.
Mora, E.
Icaza, G.
Keywords: Essentialhypertension; Cell adhesion molecules; Endothelialcells.
Issue Date: Nov-2003
Publisher: Marcel Dekker, Inc.
Citation: Clinical and Experimental Hypertension 25 (8): 517-523
Abstract: In essential hypertension (EH) patients, blood pressure can modify serum concentrations of some soluble forms of cell adhesion molecules (CAM), e.g., soluble E-selectin (sE-selectin) and soluble vascular cell adhesion molecule-1 (sVCAM-1). The objective of this study was to compare the serum levels of these CAMs in compensated (CH) and non-compensated (NCH) EH patients. Our findings show that sE-selectin and sVCAM-1 levels are higher in EH patients than normotensive subjects (sVCAM-1: 796 +/- 52 vs. 605 +/- 24 ng/mL, p < 0.0001, and sE-selectin: 71 +/- 21 vs. 48 14 ng/mL, p < 0.0001). Serum concentrations of both CAMs was higher in NCH patients than CH patients. High arterial blood pressure (ABP) may therefore increase the production of cell adhesion molecules, probably through endothelial activation.
Description: Palomo, I.; Alarcon, M.L. and Mora, E.Department of Clinical Biochemistry and Immunohematology, School of Health Sciences. University of Talca, Talca,Chile. Icaza, G. Institute of Mathematics and Physics,University of Talca, Talca,Chile.
URI: http://dspace.utalca.cl/handle/1950/3343
ISSN: 1064-1963
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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