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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4076

Title: Gastroprotective effect of the Mapuche crude drug Araucaria araucana resin and its main constituents
Authors: Schmeda-Hirschmann, G.
Astudillo, L.
Rodriguez, J.
Theoduloz, C.
Yanez, T.
Keywords: Gastroprotective activity; Araucaria araucana; Labdane diterpenes; Cytotoxicity
Issue Date: 2005
Publisher: Elsevier Ireland Ltd.
Citation: Journal of Ethnopharmacology Volume 101 (1-3): 271-276
Abstract: The resin from the tree Araucaria araucana (Araucariaceae) has been used since pre-columbian times by the Mapuche amerindians to treat ulcers. The gastroprotective effect of the resin was assessed in the ethanol–HCl-induced gastric ulcer in mice showing a dose-dependent gastroprotective activity at 100, 200 and 300 mg/kg per os. The main three diterpene constituents of the resin, namely imbricatolic acid, 15-hydroxyimbricatolal and 15-acetoxyimbricatolic acid were isolated and evaluated for gastroprotective effect at doses of 50, 100 and 200 mg/kg. A dose-related gastroprotective effect with highly significant activity (P < 0.01) was observed at doses up to 200 mg/kg. At 100 mg/kg, the highest gastroprotective activity was provided by 15-hydroxyimbricatolal and 15-acetoxyimbricatolic acid, all of them being as active as the reference drug lansoprazole at 20 mg/kg. The cytotoxicity of the main diterpenes as well as lansoprazole was studied towards human lung fibroblasts (MRC-5) and determined by the MTT reduction assay. A concentration-dependent cell viability inhibition was found with IC50 values ranging from 125 up to 290 μM. Our results support the traditional use of the Araucaria araucana resin by the Mapuche culture.
Description: Schmeda-Hirschmann, G.; Astudillo, L. Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile Rodriguez, J.; Theoduloz, C.; Yanez, T. Departamento de Ciencias Básicas Biomédicas, Facultad de Ciencias de la Salud, Universidad de Talca, Casilla 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/4076
ISSN: 0378-8741
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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