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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4077

Title: Constituents of the Argentinian medicinal plant Baccharis grisebachii and their antimicrobial activity
Authors: Schmeda-Hirschmann, G.
Feresin, G.E.
Tapia, A.
Gimenez, A.
Ravelo, A.G.
Zacchino;, S.
Sortino, M.
Keywords: Baccharis grisebachii; Asteraceae; p-Coumaric acid derivatives; Flavones; Labdane diterpenes; Antimicrobial activity
Issue Date: 2003
Publisher: Elsevier Ireland Ltd.
Citation: Journal of Ethnopharmacology 89 (1): 73-80
Abstract: The resinous exudate of Baccharis grisebachii which is used to treat ulcers, burns, and skin sores in Argentina showed activity towards dermatophytes and bacteria. Two diterpenes, eight p-coumaric acid derivatives, and two flavones were isolated from the exudate and the structures elucidated by spectroscopic methods. 3-Prenyl-p-coumaric acid and 3,5-diprenyl-p-coumaric acid were active towards Epidermophyton floccosum and Trichophyton rubrum with MICs of 50 and 100–125 μg/ml, respectively. The diterpene labda-7,13E-dien-2β,15-diol was active towards Epidermophyton floccosum and Trichophyton rubrum with MICs of 12.5 μg/ml while the MIC against Microsporum canis and Trichophyton mentagrophytes was 25 μg/ml. The diterpene was also active towards Microsporum gypseum with a MIC of 50 μg/ml, and showed inhibition in both Staphylococcus aureus (methicilline resistant and sensible strains) with MICs of 125 μg/ml. The results support the use of Baccharis grisebachii in Argentinian traditional medicine.
Description: Schmeda-Hirschmann,G. Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/4077
ISSN: 0378-8741
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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