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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4078

Title: Bioactive alkyl phenols and embelin from Oxalis erythrorhiza
Authors: Feresin, G.E.
Tapia, A.
Sortino, M.
Zacchino, S.
De Arias, A.R.
Inchaustti, A.
Yaluff, G.
Rodriguez, J.
Theoduloz, C.
Schmeda-Hirschmann, G.
Keywords: Oxalis erythrorhiza; Oxalidaceae; Embelin; Alkyl phenols; Antimicrobial and antiprotozoal activity
Issue Date: 2003
Publisher: Elsevier Ireland Ltd
Citation: Journal of Ethnopharmacology 88 (2-3): 241-247
Abstract: The benzoquinone embelin and four alkyl phenols were isolated from an Argentinean collection of Oxalis erythrorhiza. 3-Heptadecyl-5-methoxy-phenol is reported for the first time. The structures were determined by spectroscopic methods. Embelin presented inhibitory effect on methicillin-resistant Staphylococcus aureus, Escherichia coli and the dermatophytic fungi Epidermophyton floccosum, Microsporum canis, Microsporum gypseum, Trichophyton mentagrophytes and Trichophyton rubrum with MICs ranging between 50 and 100 μg/ml. Furthermore, embelin was active against Trypanosoma cruzi trypomastigotes with 100% lysis at 100 μg/ml and cytotoxicity below the trypanocidal concentration. The new alkyl phenol 3-heptadecyl-5-methoxy-phenol was active towards Leishmania amazonensis and Leishmania donovani promastigotes with 100% lysis at 100 μg/ml. The cytotoxicity (IC50) of embelin and the new alkyl phenol on human lung fibroblasts were 739 and 366 μM, respectively. The plant is used to treat heart complains, a symptomatology related to Chagas’ disease which is endemic in the San Juan Province, Argentine.
Description: Rodriguez,J.;Theoduloz,C. Laboratorio de Cultivo Celular, Facultad de Ciencias de la Salud, Universidad de Talca, Casilla 747, Talca, Chile Schmeda-Hirschmann, G. Natural Products Chemistry Laboratory, Institute of Chemistry of Natural Resources, University of Talca, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/4078
ISSN: 0378-8741
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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