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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4080

Title: Gastroprotective activity of the diterpene solidagenone and its derivatives on experimentally induced gastric lesions in mice
Authors: Schmeda-Hirschmann, G.
Rodriguez, J.
Astudillo, L.
Keywords: Solidagenone; Labdane diterpenes; Semisynthesis; Solidagen-6β-ol; Gastroprotective effect
Issue Date: 2002
Publisher: Elsevier Science Ireland Ltd.
Citation: Journal of Ethnopharmacology 81(1): 111-115
Abstract: The labdane diterpene solidagenone 1 and its semisynthetic and biotransformations products 2–7 were assessed for gastroprotective effect in the HCl·EtOH-induced lesions in mice. At 100 mg/kg, solidagenone presented a statistically significant gastroprotective effect (P<0.05) comparable to lansoprazole at 20 mg/kg. The presence of the furan ring was required for the activity of solidagenone while hydroxylation at C-3 or C-6 afforded products with different activity associated with the stereochemistry. Solidagen-6β-ol 7 and 3α-hydroxysolidagenone 2 presented higher activity than solidagenone itself, while its epimers were inactive
Description: Schmeda-Hirschmann, G.; Astudillo L. Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla Talca, 747, Chile. Rodriguez, J. Instituto de Biología Vegetal y Biotecnología, Universidad de Talca, Casilla 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/4080
ISSN: 0378-8741
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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