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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4280

Title: Gastroprotective activity of sesquiterpene derivatives from Fabiana imbricata
Authors: Reyes, M.
Schmeda-Hirschmann, G.
Razmilic, I.
Theoduloz, C.
Yanez, T.
Rodriguez, J.
Keywords: Fabiana imbricata; Solanaceae; 11-hydroxy-4-amorphen-15-oic acid; sesquiterpene derivatives; gastroprotective effect; cytotoxicity
Issue Date: 2005
Publisher: John Wiley & Sons Ltd.
Citation: Phytotherapy Research 19(12):1038 - 1042
Abstract: An infusion or decoction of the aerial parts of Fabiana imbricata (Solanaceae) is used in traditional medicine in Chile and Argentina as a digestive and diuretic agent. The main sesquiterpene of the plant was identified as 11-hydroxy-4-amorphen-15-oic acid. At doses of 25, 50 and 100 mg/kg, the compound showed a dose-dependent gastroprotective effect in HCl/EtOH-induced gastric lesions in mice reducing the lesions by 68% at 100 mg/kg. Seven derivatives of the terpene were prepared and their gastroprotective effect was assessed in HCl/EtOH-induced gastric lesions in mice. The cytotoxicity of the products was evaluated in fibroblasts and AGS cells. At 100 mg/kg, 11-hydroxy-4-amorphen-15-p-toluidinamide presented the best gastroprotective effect reducing the gastric lesions by 80%, showing a similar effect to lansoprazole at 20 mg/kg. The compound, however, presented higher cytotoxicity than other derivatives with the IC50 ranging between 110 and 145 µm in AGS cells and fibroblasts, respectively. Most compounds proved to be non-toxic showing cytotoxicity values higher than 1000 µm. The spectroscopic data of six 11-hydroxy-4-amorphen-15-oic acid derivatives are presented here for the first time.
Description: Reyes, M.; Schmeda-Hirschmann, G.; Razmilic, I. Laboratorio de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile. Theoduloz, C.; Yáñez, T.; Rodríguez, J. Departamento de Ciencias Básicas Biomédicas, Facultad de Ciencias de la Salud, Universidad de Talca, Casilla 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/4280
ISSN: 0951-418X
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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