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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4282

Title: Biological activity and xanthine oxidase inhibitors from Scirpus californicus (C A Mey) Steud
Authors: Schmeda-Hirschmann, G.
Gutierrez, M.I.
Loyola, J.I.
Zuniga, J.
Keywords: Scirpus californicus; Cyperaceae; xanthine oxidase inhibition; piceatannol; scirpusin A and B
Issue Date: 1996
Publisher: John Wiley & Sons Ltd.
Citation: Phytotherapy Research 10 (8): 683-685
Abstract: The methanol extract of the rhizomes of Scirpus californicus (Cyperaceae) inhibited the enzyme xanthine oxidase (XO) in vitro. Bioassay-guided isolation led to piceatannol, scirpusin A and scirpusin B as the main XO inhibitors of S. californicus. Piceatannol, scirpusin A and B were mixed-type inhibitors of the XO with Ki values of 1.1×10-4, 6×10-4 and 5×10-5 M, respectively. The extract and above mentioned compounds were marginally active as hypotensors when tested in normotensive rats at 2.5 mg/kg and were inactive towards the DNA binding assay in vitro
Description: Schmeda-Hirschmann, G. Departamento de Ciencias Biologicas, Universidad de Talca, Casilla 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/4282
ISSN: 0951-418X
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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