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| Title: | Biological activity and xanthine oxidase inhibitors from Scirpus californicus (C A Mey) Steud |
| Authors: | Schmeda-Hirschmann, G.
Gutierrez, M.I.
Loyola, J.I.
Zuniga, J. |
| Keywords: | Scirpus californicus; Cyperaceae; xanthine oxidase inhibition; piceatannol; scirpusin A and B |
| Issue Date: | 1996 |
| Publisher: | John Wiley & Sons Ltd. |
| Citation: | Phytotherapy Research 10 (8): 683-685 |
| Abstract: | The methanol extract of the rhizomes of Scirpus californicus (Cyperaceae) inhibited the enzyme xanthine oxidase (XO) in vitro. Bioassay-guided isolation led to piceatannol, scirpusin A and scirpusin B as the main XO inhibitors of S. californicus. Piceatannol, scirpusin A and B were mixed-type inhibitors of the XO with Ki values of 1.1×10-4, 6×10-4 and 5×10-5 M, respectively. The extract and above mentioned compounds were marginally active as hypotensors when tested in normotensive rats at 2.5 mg/kg and were inactive towards the DNA binding assay in vitro |
| Description: | Schmeda-Hirschmann, G. Departamento de Ciencias Biologicas, Universidad de Talca, Casilla 747, Talca, Chile. |
| URI: | http://dspace.utalca.cl/handle/1950/4282 |
| ISSN: | 0951-418X |
| Appears in Collections: | Artículos en publicaciones ISI - Universidad de Talca
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