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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4283

Title: Antiprotozoal activity of Jatrogrossidione from Jatropha grossidentata and Jatrophone from Jatropha isabellii
Authors: Schmeda-Hirschmann, G.
Razmilic, I.
Sauvain, M.
Moretti, C.
Munoz, V.
Ruiz, E.
Balanza, E.
Fournet, A.
Keywords: Jatropha grossidentata; Jatropha isabellii; Euphorbiaceae; antiprotozoal; Leishmania; Trypanosona cruzi; jatrogrossidione; jatrophone
Issue Date: 1999
Publisher: John Wiley & Sons Ltd.
Citation: Phytotherapy Research 10 (5): 375 - 378
Abstract: The activity of jatrogrossidione, the main diterpene of Jatropha grossidentata and jatrophone from Jatropha isabellii was determined against Leishmania and Trypanosoma cruzi strains in vitro as well as against Leishmania amazonensis in vivo. Jatrogrossidione showed a strong in vitro leishmanicidal and trypanocidal activity with IC100 of 0.75 and 1.5-5.0 g/mL, respectively. Under similar conditions, the IC100 of glucantime, ketoconazole and pentamidine towards Leishmania strains were >100, 50-100 and 1 g/mL, respectively. The IC50 of jatrogrossidione was <0.25 g/mL against amastigote forms of Leishmania infecting macrophages, with toxicity at concentrations higher than 0.5 g/mL.
Description: Schmeda Hirschman, G.; Razmilic, I. Departamento de Ciencias Biológicas, Universidad de Talca, Casilla 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/4283
ISSN: 0951-418X
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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