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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4284

Title: Xanthine oxidase inhibitory activity of flavonoids and tannins from Hexachlamys edulis (Myrtaceae)
Authors: Schmeda-Hirschmann, G.
Dutra-Behrens, M.
Habermehl, G.
Zuniga, J.
Keywords: Hexachlamys edulis; Myrtaceae; pentagalloylglucose; desmanthin-1; (-)-epigallocatechin-3-O-gallate; xanthine oxidase inhibitors: flavonoid glycosides
Issue Date: 1996
Publisher: John Wiley & Sons Ltd.
Citation: Phytotherapy Research 10(3):260 - 262
Abstract: The acetone-water extract of Hexachlamys edulis (Myrtaceae) inhibited the enzyme xanthine oxidase (XO) in vitro. Bioassay-guided isolation led to the gallic acid ester in 2 of myricitrin (desmanthin-1), (-)-epigallocatechin-3-O-gallate (EGG) and pentagalloylglucose as the main XO inhibitors of H. edulis. Desmanthin-1 and EGG were mixed-type inhibitors of XO with Ki values of 1.6×10-4 M and 1.8×10-4 M, respectively. Pentagalloylglucose was an uncompetitive XO inhibitor with a KESI of 6.7×10-6M. From the active n-butanol soluble part of the aqueous acetone extract of H. edulis, several flavonoids were isolated. The flavonoids were mainly myricetin-3-O-monoglycosides with the quercetin glycoside avicularin as a minor compound displaying a weak inhibitory activity towards XO.
Description: Schmeda-Hirschmann, G. and Zúñiga, J. Departamento de Ciencias Biológicas, Universidad de Talca, Casilla 747, Talca, Chile
URI: http://dspace.utalca.cl/handle/1950/4284
ISSN: 0951-418X
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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