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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4301

Title: Factor V Leiden y mutación de la protrombina G20210A en pacientes con trombosis venosa y arterial
Other Titles: Factor V Leiden and prothrombin G20210A among Chilean patients with venous and arterial thrombosis
Authors: Palomo, I.
Pereira, J.
Alarcon, M.
Pinochet, C.
Velez, M.T.
Hidalgo, P.
Skagerberg, K.
Poblete, F.
Keywords: Factor V: deficiency; Prothrombin; Thromboembolism; Venous thrombosis
Issue Date: 2005
Publisher: Publicación del Sociedad Médica de Santiago
Citation: Revista Medica de Chile 133 (12): 1425-1433
Abstract: Factor V Leiden and G20210A mutation of prothrombin gene are two important genetic polymorphisms associated with an increased risk for thrombosis. Aim: To establish the prevalence of factor V Leiden and prothrombin G20210A mutation in the Chilean population and their association to venous and arterial thromboembolism. Material and methods: A case-control study was conducted where 149 patients with thrombosis (87 with arterial and 62 with venous thrombosis) confirmed by CAT-scan, electrocardiogram and cardiac enzymes or Doppler depending on the case, and 160 healthy blood donors were genetically analyzed for the presence of both polymorphisms. Results: Factor V Leiden mutation was found in 5.4% of patients and in 1.3% of healthy controls (p=0.04). Heterozygosity for G20210A prothrombin mutation was found in 5.4% of patients and in 2.5% of the control group (p=NS). When arterial and venous thrombosis were considered as separate entities, 4.6% of patients with arterial thrombosis and 6.5% with venous thrombosis presented factor V Leiden (p=NS). Likewise, 8.1% of patients with venous thrombosis and 3.5% of patients with arterial thrombosis had G20210A prothrombin mutation (p=NS). Conclusions: In non selected consecutive Chilean patients with arterial and venous thrombosis the frequency of factor V Leiden and prothrombin G20210A is less than we could expect from their prevalence in the general population
Description: Iván Palomo. Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud. Universidad de Talca, Talca, Chile. Casilla 747,Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/4301
ISSN: 0034-9887
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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