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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4331

Title: Activity of solidagenone and their semisynthetic derivatives on the glucocorticoid-mediated signal transduction
Authors: Razmilic, I.
Schmeda-Hirschmann, G.
Keywords: Diterpene ; Rhizome ; Biological activity ; Signal transduction ; Glucocorticoid ; Antiinflammatory agent ; Plant origin ; Pharmacognosy ; Medicinal plant ; Chile ; Compositae ; Dicotyledones ; Angiospermae ; Spermatophyta ; South America ; America ;
Issue Date: 2000
Publisher: George Thieme
Citation: Planta Medica 66 (1):86-88
Abstract: The labdane diterpene solidagenone and four semisynthetic derivatives were assessed for effects on the glucocorticoid-mediated signal transduction. Solidagenone and the derivatives proved to be active with IC[50] values between 1 and 25 μg/mL. All compounds were cytotoxic towards L 1210, BHK and COS 7 cells with IC[50] from 10-100 μg/mL.
Description: Razmilic, I.; Schmeda-Hirschmann, G. Instituto de Quimica de Recursos Naturales, Universidad de Talca, Talca, CHILI.
URI: http://dspace.utalca.cl/handle/1950/4331
ISSN: 0032-0943
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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