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| Title: | Activity of solidagenone and their semisynthetic derivatives on the glucocorticoid-mediated signal transduction |
| Authors: | Razmilic, I.
Schmeda-Hirschmann, G. |
| Keywords: | Diterpene ; Rhizome ; Biological activity ; Signal transduction ; Glucocorticoid ; Antiinflammatory agent ; Plant origin ; Pharmacognosy ; Medicinal plant ; Chile ; Compositae ; Dicotyledones ; Angiospermae ; Spermatophyta ; South America ; America ; |
| Issue Date: | 2000 |
| Publisher: | George Thieme |
| Citation: | Planta Medica 66 (1):86-88 |
| Abstract: | The labdane diterpene solidagenone and four semisynthetic derivatives were assessed for effects on the glucocorticoid-mediated signal transduction. Solidagenone and the derivatives proved to be active with IC[50] values between 1 and 25 μg/mL. All compounds were cytotoxic towards L 1210, BHK and COS 7 cells with IC[50] from 10-100 μg/mL. |
| Description: | Razmilic, I.; Schmeda-Hirschmann, G. Instituto de Quimica de Recursos Naturales, Universidad de Talca, Talca, CHILI. |
| URI: | http://dspace.utalca.cl/handle/1950/4331 |
| ISSN: | 0032-0943 |
| Appears in Collections: | Artículos en publicaciones ISI - Universidad de Talca
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