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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4531

Title: Synthesis, antimycobacterial activities and cytotoxicity on V79 of 3-[4′-Y-(1,1′-biphenyl)-4-yl]-N,N-dimethyl-3-(4-X-phenyl)-2-propen-1-amine derivatives
Authors: de Souza, A.O.
Junior, R.R.S.
Ferreira-Julio, J.F.
Rodriguez, J.
Melo, P.S.
Haun, M.
Sato, D.N
Duran, N.
Keywords: synthesis; cytotoxicity; V79 cells; antimycobacterial activity; 2-propen-1-amine
Issue Date: 2001
Publisher: Elsevier SAS.
Citation: European Journal of Medicinal Chemistry 36 (10): 843-850
Abstract: The derivatives of 3-(4′-bromo-[1,1′-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine (5a–m) were synthesised through a Friedel–Crafts acylation followed by Wittig reaction. The effects of the compounds on standard strains of Mycobacterium sp. (ATCC) and M. tuberculosis isolated from clinical specimens were evaluated. Also the toxicity was determined on V79 cells line using neutral red uptake (NRU), nucleic acid content (NAC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction to measure the cellular viability.
Description: Rodriguez, J. Departamento de Ciencias Biomedicas, Facultad de Ciencias de la Salud, Universidad de Talca, Casilla 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/4531
ISSN: 0223-5234
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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