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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4590

Title: Free radical scavengers, anti-inflammatory and analgesic activity of Acaena magellanica
Authors: Feresin, G.E.
Tapia; A.
Gutierrez, A.
Delporte, C.
Erazo, N.B.
Schmeda-Hirschmann, G.
Issue Date: 2002
Publisher: Pharmaceutical Press
Citation: Journal of Pharmacy and Pharmacology 54 (6): 835-844
Abstract: Extracts of the whole plant Acaena magellanica (Rosaceae) were assessed for anti-inflammatory, antipyretic and analgesic activity in animal models. At 600 mg kg-1, the global ethanolic extract (GEE), dichloromethane (DCM) and defatted methanol (MeOH) fractions showed a mild anti-inflammatory effect in the carrageenan-induced guinea-pig paw oedema. The GEE, DCM and defatted MeOH fractions significantly reduced inflammation by 43.2, 40.5 and 42.1%, respectively. The GEE did not showed any significant antipyretic activity in doses up to 600 mg kg-1. A 20% w/v infusion administered orally at 16 mL kg-1 presented analgesic effect in the acetic acid-induced abdominal constriction test in mice. The GEE and MeOH extract of A. magellanica showed free radical scavenging activity in the diphenylpicrylhydrazyl decolouration assay. Assay-guided isolation led to quercetin, Q-3-O--D-glucoside, Q-3-O--D-galactoside, ellagic acid and catechin as the free radical scavengers. The saponins tormentic acid 28-O--D-galactopyranoside and 28-O--D-glucopyranoside were isolated from the polar extract. The structures were determined by spectroscopic methods.
Description: Schmeda-Hirschmann, G.Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/4590
ISSN: 0022-3573
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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