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|Title: ||Gastroprotective activity of solidagenone on experimentally-induced gastric lesions in rats|
|Authors: ||Rodriguez, J.|
|Issue Date: ||2002 |
|Publisher: ||Pharmaceutical Press|
|Citation: ||Journal of Pharmacy and Pharmacology 54 (3): 399 - 404|
|Abstract: ||The gastroprotective effect of the labdane diterpene solidagenone was assessed on gastric ulcer in rats. The effect of a single oral dose of the compound was evaluated at 50, 100 and 200 mg kg-1 in the following test systems: pylorus ligature (Shay), aspirin- and ethanol-induced gastric ulcers. In pylorus-ligated rats (Shay model), the ulcerative index decreased by 37% with solidagenone pre-treatment at the three assayed doses. The effect of a single oral dose of 50 mg kg-1 solidagenone was comparable with ranitidine at the same concentration and similar to higher doses of the compound. A significant effect (P< 0.001) at 100 and 200 mg kg-1 was observed in the aspirin-induced ulcer model. At both doses, reduction in the number of lesions was approximately 50% compared with controls. The effect was comparable with the reference compound ranitidine (50 mg kg-1). With the ethanol-induced gastric ulcers, the effect of solidagenone at 100 and 200 mg kg-1 was similar to a single oral dose of 20 mg kg-1 omeprazole with a 50% reduction of the mean number of lesions compared with controls. In acute toxicity tests on mice, intraperitoneal administration of solidagenone showed no toxicity at doses up to 600 mg kg-1. This is the first report on the gastroprotective activity of a labdane diterpene.|
|Description: ||Rodríguez J. A. Instituto de Biología Vegetal y Biotecnología, Universidad de Talca, Casilla 747, Talca, Chile.
Bustamante C.; Astudillo L.; Schmeda-Hirschmann G.Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile.|
|Appears in Collections:||Artículos en publicaciones ISI - Universidad de Talca|
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