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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4592

Title: Cryptofolione derivatives from Cryptocarya alba fruits
Authors: Astudillo, L.
Bastida, J.
Codina, C.
De Arias, A.R.
Ferreira, M.E.
Schmeda-Hirschmann, G.
Inchaustti, A.
Yaluff, G.
Issue Date: 2001
Publisher: Pharmaceutical Press
Citation: Journal of Pharmacy and Pharmacology 53 (4): 563-567
Abstract: Cryptofolione (1) and the new cryptofolione derivative 6-(4,6-dimethoxy-8-phenyl-octa-1,7-dienyl)-4-hydroxy-tetrahydro-pyran-2-one (2) were isolated from the fruits of Cryptocarya alba. The structures were elucidated by spectroscopic methods. Cryptofolione showed activity towards Trypanosoma cruzi trypomastigotes, reducing their number by 77% at 250g mL-1. Cryptofolione showed moderate cytotoxicity in both macrophages and T. cruzi amastigotes. It also displayed a mild inhibitory effect on the promastigote form of Leishmania spp. As both cytotoxic and trypanocidal effects are similar, the compound presented little selectivity in our assay models.
Description: Schmeda-Hirschmann G.; Astudillo L. Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/4592
ISSN: 0022-3573
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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