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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4618

Title: Hypoglycaemic activity of Geranium core-core, Oxalis rosea and Plantago major extract in rats
Authors: Rodriguez, J.
Loyola, J.I.
Maulen, G.
Schmeda-Hirschmann, G.
Keywords: Geranium core-core; Oxalis rosea; Plantago major; hypoglycaemic activity; oral toxicity in rats
Issue Date: 1994
Publisher: John Wiley & Sons, Ltd.
Citation: Phytotherapy Research 8 (6): 372 - 374
Abstract: The hypoglycaemic activity of Core-core (Geranium core-core, Geraniaceae), Culle (Oxalis rosea, Oxalidaceae) and Llantén (Plantago major, Plantaginaceae) crude extracts was assessed in normoglycaemic rats. Furthermore, the hypoglycaemic activity of Core-core extract was evaluated in alloxan-diabetic rats. A single oral dose of 500 mg/kg Core-core extract significantly reduced glycaemia in normal rats under glucose tolerance test conditions (p < 0.01), while Culle and Llantén were devoid of activity. The effect was lower than a single oral dose of 100 mg/kg tolbutamide. After 7 days oral treatment at 250 mg extract/kg body weight, Core-core significantly reduced glycaemia (p<0.01) in normal rats under oral glucose tolerance conditions. In alloxan-diabetic rats, a single oral dose of 500 mg/kg and chronic treatment at 250 mg/kg Core-core extract significantly reduced glycaemia in glucose tolerance test conditions at p < 0.05 and p < 0.01, respectively. During the acute oral toxicity study, animals treated with Core-core extract exhibited no symptoms of drug-induced toxicity with doses up to 5 g/kg.
Description: J. Rodriguez, J. I. Loyola, G. Maulén, G. Schmeda-Hirschmann. Departamento de Ciencias Biológicas, Universidad de Talca, Casilla 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/4618
ISSN: 0951-418X
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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