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|Title: ||Hypoglycaemic activity of Geranium core-core, Oxalis rosea and Plantago major extract in rats|
|Authors: ||Rodriguez, J.|
|Keywords: ||Geranium core-core; Oxalis rosea; Plantago major; hypoglycaemic activity; oral toxicity in rats|
|Issue Date: ||1994 |
|Publisher: ||John Wiley & Sons, Ltd.|
|Citation: ||Phytotherapy Research 8 (6): 372 - 374|
|Abstract: ||The hypoglycaemic activity of Core-core (Geranium core-core, Geraniaceae), Culle (Oxalis rosea, Oxalidaceae) and Llantén (Plantago major, Plantaginaceae) crude extracts was assessed in normoglycaemic rats. Furthermore, the hypoglycaemic activity of Core-core extract was evaluated in alloxan-diabetic rats. A single oral dose of 500 mg/kg Core-core extract significantly reduced glycaemia in normal rats under glucose tolerance test conditions (p < 0.01), while Culle and Llantén were devoid of activity. The effect was lower than a single oral dose of 100 mg/kg tolbutamide. After 7 days oral treatment at 250 mg extract/kg body weight, Core-core significantly reduced glycaemia (p<0.01) in normal rats under oral glucose tolerance conditions. In alloxan-diabetic rats, a single oral dose of 500 mg/kg and chronic treatment at 250 mg/kg Core-core extract significantly reduced glycaemia in glucose tolerance test conditions at p < 0.05 and p < 0.01, respectively. During the acute oral toxicity study, animals treated with Core-core extract exhibited no symptoms of drug-induced toxicity with doses up to 5 g/kg.|
|Description: ||J. Rodriguez, J. I. Loyola, G. Maulén, G. Schmeda-Hirschmann.
Departamento de Ciencias Biológicas, Universidad de Talca, Casilla 747, Talca, Chile.|
|Appears in Collections:||Artículos en publicaciones ISI - Universidad de Talca|
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