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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4621

Title: Hypotensive effect of Laurelia sempervirens (Monimiaceae) on normotensive rats
Authors: Schmeda-Hirschmann, G.
Loyola, J.I.
Rodriguez, J.
Dutra-Behrens, M.
Keywords: Laurelia sempervirens; Monimiaceae; hypotensive effect; oral toxicity in rats: laurotetanine; alkaloids.
Issue Date: 1994
Publisher: John Wiley & Sons Ltd.
Citation: Phytotherapy Research 8 (1): 49-51
Abstract: The leaves of Laurelia sempervirens (Monimiaceae), an endemic Chilean tree known as Laurel, were used by the Mapuche Amerindians for treating headache and as a diuretic. Intravenous administration of a hydroalcoholic L. sempervirens extract to rats, elicited a hypotensive response of -27.0%±2.0% in the mean blood pressure of normotensive animals at a dose of 5 mg crude extract ± kg body weight. Bioassay-guided isolation of the active Laurel metabolites led to the alkaloid laurotetanine as the main hypotensive principle of L. sempervirens leaves. At 1 mg/kg body weight, laurotetanine produced a hypotensive response of -29.0%±2.1% in the mean blood pressure of normotensive rats, with a duration of 2 min, both comparable to those elicited by the crude extract at 5 mg/kg. In the acute oral toxicity study, Laurel proved to be a very low toxicity crude drug at doses up to 3 g crude extract/kg body weight. The data obtained support the use of L. sempervirens in Mapuche traditional medicine.
Description: G. Schmeda-Hirschmann, J. I. Loyola, J. Rodriguez, M. Departamento de Ciencias Biolögicas, Universidad de Talca, Casilla 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/4621
ISSN: 0951-418X
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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