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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4875

Title: Probing the mechanism of direct Mannich-type alpha-methylenation of ketoesters via electrospray ionization mass spectrometry
Authors: Milagre, C.D.F.
Milagre, H.M.S.
Santos, L.S.
Lopes, M.L.A.
Moran, P.J.S.
Eberlin, M.N.
Rodrigues, J.A.R.
Keywords: ketoesters;-methylenation; electrospray ionization mass spectrometry; reaction mechanisms
Issue Date: 2007
Publisher: Wiley Interscience
Citation: Journal of Mass Spectrometry 42 (10):1287-1293
Abstract: Reactions promoting direct Mannich-type -methylenation of , and -ketoesters have been monitored via electrospray ionization mass and tandem mass spectrometric experiments. Key intermediates of the catalytical cycle of this synthetically useful reaction have been intercepted and characterized. The mechanistic information provided by electrospray ionization mass spectrometry/mass spectrometry (ESI-MS/MS) guided the optimization of reaction conditions, allowing -methyleneketoesters to be prepared in high yields (80-95%) and in high-enough purity for immediate further manipulation. Copyright © 2007 John Wiley & Sons, Ltd.
Description: Leonardo S. Santos. Instituto de Química de Recursos Naturales, Universidad de Talca, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/4875
ISSN: 1076-5174
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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