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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4880

Title: An insight into the pathophysiology of thrombosis in antiphospholipid syndrome
Authors: Palomo, I.
Segovia, F.M.
Alarcon, M.
Fuentes, B.Y.
Pereira, J.G.
Rojas, A
Forastiero, R.
Keywords: antiphospholipid syndrome; antiphospholipid antibodies; beta 2 glycoprotein I; thrombosis; review
Issue Date: 2007
Citation: Frontiers in bioscience 12: 3093 - 3103
Abstract: The antiphospholipid syndrome (APS) is a disorder which is characterized by the presence of autoimmune antiphospholipid antibodies ( APL) and increased risk of thrombosis and fetal loss. APL are associated with recurrent abortions in APS patients and participate in the pathogenesis of venous or arterial thrombosis, although the underlying mechanisms are poorly understood. Antigens that are targeted by APL include beta 2 glycoprotein I and prothrombin. Pathological mechanisms of APL encompass inhibition of natural anticoagulants ( protein C system, tissue factor pathway inhibitor, and annexin A5), inhibition of the fibrinolytic system, activation of endothelial cells, monocytes and platelets, and complement activation. In this review, we discuss the main targets of APL and prothrombogenic mechanisms of APL.
URI: http://dspace.utalca.cl/handle/1950/4880
ISSN: 1093-9946]
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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