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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/4897

Title: Biotransformations of imbricatolic acid by Aspergillus niger and Rhizopus nigricans cultures
Authors: Schmeda-Hirschmann, G.
Aranda, C.
Kurina, M.
Rodriguez, J.
Theoduloz, C.
Keywords: Aspergillus niger, Rhizopus nigricans, imbricatolic acid, biotransformation,
Issue Date: 2007
Citation: Molecules 12 (5):1092-1100
Abstract: Microbial transformation of imbricatolic acid (1) by Aspergillus niger afforded 1α-hydroxyimbricatolic acid (2), while transformation with Rhizopus nigricans yielded 15- hydroxy-8,17-epoxylabdan-19-oic acid (3). When the diterpene 1 was added to a Cunninghamella echinulata culture, the main products were the microbial metabolites mycophenolic acid (4) and its 3-hydroxy derivative 5. All the structures were elucidated by spectroscopic methods. The cytotoxicity of these compounds towards human lung fibroblasts and AGS cells was assessed. While 4 and 5 showed low cytotoxicity, with IC50 values > 1000 μM against AGS cells and fibroblasts, 1α-hydroxyimbricatolic acid (2) presented moderate toxicity towards these targets, with IC50 values of 307 and 631 μM, respectively. The structure of 2 is presented for the first time.
Description: Guillermo Schmeda-Hirschmann and Carlos Aranda Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile. Jaime A. Rodríguez and Cristina Theoduloz. Depto. de Ciencias Básicas Biomédicas, Facultad de Ciencias de la Salud, Universidad de Talca, Casilla 747, Talca, Chile
URI: http://dspace.utalca.cl/handle/1950/4897
ISSN: 1420-3049
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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