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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/8768

Title: Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives
Authors: Pertino, M.W.
Theoduloz, C.
Palenzuela, J.A.
Afonso, M.D.
Yesilada, E.
Monsalve, F.
Gonzalez, P.
Droguett, D.
Schmeda-Hirschmann, G.
Keywords: labdane diterpenes
lapachol derivatives
diterpenylnaphthoquinones
gastroprotection
basal cytotoxicity
Issue Date: Oct-2011
Publisher: MDPI AG
Citation: MOLECULES Volume: 16 Issue: 10 Pages: 8614-8628 DOI: 10.3390/molecules16108614 Published: OCT 2011
Abstract: New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.
Description: Schmeda-Hirschmann, G (reprint author), Univ Talca, Inst Quim Recursos Nat, Casilla 747, Talca, Chile
URI: http://dspace.utalca.cl/handle/1950/8768
ISSN: 1420-3049
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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