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| Title: | Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives |
| Authors: | Pertino, M.W.
Theoduloz, C.
Palenzuela, J.A.
Afonso, M.D.
Yesilada, E.
Monsalve, F.
Gonzalez, P.
Droguett, D.
Schmeda-Hirschmann, G. |
| Keywords: | labdane diterpenes
lapachol derivatives
diterpenylnaphthoquinones
gastroprotection
basal cytotoxicity |
| Issue Date: | Oct-2011 |
| Publisher: | MDPI AG |
| Citation: | MOLECULES Volume: 16 Issue: 10 Pages: 8614-8628 DOI: 10.3390/molecules16108614 Published: OCT 2011 |
| Abstract: | New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells. |
| Description: | Schmeda-Hirschmann, G (reprint author), Univ Talca, Inst Quim Recursos Nat, Casilla 747, Talca, Chile |
| URI: | http://dspace.utalca.cl/handle/1950/8768 |
| ISSN: | 1420-3049 |
| Appears in Collections: | Artículos en publicaciones ISI - Universidad de Talca
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