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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/8815

Title: Anti-inflammatory, antinociceptive, and antipyretic effects of methanol extract of Cariniana rubra stem bark in animal models
Authors: Santos, E.N.
Lima, J.C.S.
Noldin, V.F.
Cechinel, V.
Rao, V.S.N.
Lima, E.F.F.
Schmeda-Hirschmann, G.
Sousa, P.T.
Martins, D.T.O.
Keywords: anti-inflammatory
antinociceptive
antipyretic
Cariniana rubra
Lecythidaceae
triterpenoidal saponins
Issue Date: Jun-2011
Publisher: ACAD BRASILEIRA DE CIENCIAS
Citation: ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS Volume: 83 Issue: 2 Pages: 557-566
Abstract: Cariniana rubra Miers (Lecythidaceae), popularly known as "jequitiba-vermelho", is a large Brazilian tree whose bark is used in infusion and decoction for the treatment of inflammatory conditions. This study aims to assess the anti-inflammatory, antinociceptive, and antipyretic effects of Cariniana rubra methanolic stem bark extract (EMCr) using experimental animals. Anti-inflammatory activity of EMCr was tested on carrageenan and dextran-induced rat paw edema, carrageenan-induced pleurisy in rats and acetic acid-increase vascular permeability in mice. Antinociceptive and antipyretic activities were evaluated using acetic acid-induced writhing, formalin and hot-plate tests in mice, as well as brewer's yeast-induced pyrexia in rats. The extract inhibitied carrageenan and dextran-induced edema, reduced exudate volume and leukocyte migration on the carrageenan-induced pleurisy and on the vascular permeability increase induced by acetic acid. The EMCr inhibited nociception on the acetic acid-induced writhing and in the second phase of formalin test, and decreased rectal temperature. It was, however, inactive against thermal nociception. Phytochemical analysis with EMCr showed the occurrence of saponins, triterpenes, sterols and phenolic compounds. Phytosterols (beta-sitosterol, stigmasterol), pentacyclic triterpenes (alpha- and beta-amyrin as a mixture), arjunolic acid, a phytosterol glycoside (sitosterol 3-O-beta-D-glucopyranoside), and triterpenoid saponins (28-beta-glucopyranosyl-23-O-acetyl arjunolic acid; 3-O-beta-glucopyranosyl arjunolic acid and 28-O-[alpha-L-Rhamnopyranosyl-(1 -> 2)-beta-glucopyranosyl]-23-O-acetyl arjunolic acid) were the main identified compounds. It can be presumed that EMCr caused their effects by inhibiting the liberation and/or action of different inflammatory mediators. These findings support the traditional use of Cariniana rubra preparations to treat inflammation.
Description: Schmeda-Hirschmann, G (Schmeda-Hirschmann, Guillermo) Univ Talca, IQRN, Talca, Chile
URI: http://dspace.utalca.cl/handle/1950/8815
ISSN: 0001-3765
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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