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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/8823

Title: Monitoring of beta-Blockers Ozone Degradation via Electrospray Ionization Mass Spectrometry
Authors: Quispe, C.
Nachtigall, F.M.
Fonseca, M.F.R.
Alberici, R.M.
Keywords: ozonation;
degradation
ESI-MS
pharmaceutical compounds; reaction mechanism
reaction mechanism
Issue Date: May-2011
Publisher: SOC BRASILEIRA QUIMICA
Citation: OURNAL OF THE BRAZILIAN CHEMICAL SOCIETY Volume: 22 Issue: 5 Pages: 919-928
Abstract: The structures of intermediate products of ozone degradation of different pharmaceutical compounds have been studied. Under the conditions employed, complete ozone degradation of nadolol was achieved after 100 min. The degradation products obtained in aqueous solution were characterized by electrospray ionization mass (and tandem mass) spectrometry (ESI-MS and ESI-MS/MS). The proposed mechanism for degradation, ozone attacks at the aniline amino group giving rise to nitro compounds and further degradation occurs via a series of oxidative processes. Continuous online monitoring by ESI-MS(/MS) with high accuracy mass measurements showed that ozone degradation of atenolol (ATE) and acebutolol (ACE) occurs via mechanisms similar to that of nadolol
Description: Santos, LS (reprint author), Talca Univ, Lab Asymmetr Synth, POB 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/8823
ISSN: 0103-5053
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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