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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/8884

Title: Supramolecular complexes of quantum dots and a polyamidoamine (PAMAM)-folate derivative for molecular imaging of cancer cells
Authors: Geraldo, D.A.
Duran-Lara, E.F.
Aguayo, D.
Cachau, R.E.
Tapia, J.
Esparza, R.
Yacaman, M.J.
Gonzalez-Nilo, F.D.
Santos, L.S.
Keywords: Quantum dots
PAMAM dendrimers
Supramolecular complexes
Transmission electron microscopy (TEM)
Molecular dynamics (MD) simulations
Gastric cancer cells
Issue Date: Apr-2011
Publisher: SPRINGER HEIDELBERG
Citation: ANALYTICAL AND BIOANALYTICAL CHEMISTRY Volume: 400 Issue: 2 Pages: 483-492
Abstract: olyamidoamine (PAMAM) dendrimers and water-soluble 3-mercaptopropionic acid (MPA)-capped CdSe quantum dots (QDs) were combined to produce a new gel containing supramolecular complexes of QDs/PAMAM dendrimers. The formation of the QDs/PAMAM supramolecular complexes was confirmed by high resolution electron microscopy and Fourier transform infrared (FTIR) analyses. Molecular dynamics simulations corroborated the structure of the new QDs/PAMAM-based supramolecular compound. Finally, on the basis of the prominent fluorescent properties of the supramolecular complexes, PAMAM dendrimer was functionalized with folic acid to produce a new QDs/PAMAM-folate derivative that showed an efficient and selective performance as a marker for gastric cancer cells.
Description: Geraldo, DA (Geraldo, Daniela A.)1,2;Duran-Lara, EF (Duran-Lara, Esteban F.)1;Tapia, J (Tapia, Jaime)1; Gonzalez-Nilo, FD (Gonzalez-Nilo, Fernando Danilo)2; Santos, LS (Santos, Leonardo S.)1.........../1. Univ Talca, Lab Asymmetr Synth, Chem Inst Nat Resources, Talca, Chile 2. Univ Talca, Ctr Bioinformat & Mol Simulat, Talca, Chile
URI: http://dspace.utalca.cl/handle/1950/8884
ISSN: 1618-2642
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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