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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/9098

Title: Gene expression of adipose tissue, endothelial cells and platelets in subjects with metabolic syndrome (Review)
Authors: Perez, M.P.
Moore-Carrasco, R.
Gonzalez, R.D.
Fuentes, Q.E.
Palomo, G.I.
Keywords: metabolic syndrome
endothelial dysfunction
adipose tissue
platelets
transcription factors
Issue Date: May-2012
Publisher: SPANDIDOS PUBL LTD, POB 18179, ATHENS, 116 10, GREECE
Citation: MOLECULAR MEDICINE REPORTS Volume: 5 Issue: 5 Pages: 1135-1140 DOI: 10.3892/mmr.2012.785
Abstract: Metabolic syndrome is a combination of medical disorders including hypertension, dyslipidemia, hyperglycemia, insulin resistance and increased waist circumference, and is associated with a higher risk of cardiovascular disease. An increase in adipose tissue mass is associated with the augmented secretion of certain adipokines, such as interleukin-6, tumor necrosis factor-a and resistin, which cause endothelial dysfunction (an increase in vasoconstrictor molecules and in the expression of adhesion molecules as well as a decrease of vasodilator molecules, amongst other features) and hemostasis alterations that also favor a prothrombotic state (increased fibrinogen and plasminogen activator inhibitor-1 concentrations and platelet activation/aggregation). This interaction between adipose tissue, endothelial cells and platelets is associated with an increase or decrease in the expression of several transcription factors (peroxisome proliferator-activated receptors, CCAAT-enhancer-binding proteins, carbohydrate responsive element-binding proteins and sterol regulatory element-binding proteins) that play a crucial role in the regulation of distinct metabolic pathways related to the metabolic syndrome. In the present review, we present the primary changes in adipose tissue, endothelial cells and platelets in subjects with metabolic syndrome and their possible target sites at the gene expression level.
Description: Palomo, GI (reprint author), Univ Talca, Dept Clin Biochem & Immunohematol, Fac Hlth Sci, PIERECV, Mailbox 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/9098
ISSN: 1791-2997
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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