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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/9117

Title: Biological activities and correlations tendency of electrochemical properties of some Indolizino[1,2-B] Quinoline Derivates
Authors: Canete, A.
Armijo, F.
Del Valle, M.A.
Tapia, R.A.
Theoduloz, C.
Pessoa, C.D.
Cantuarias, L.
Recabarren, G.
Keywords: Quinone
Electrochemical properties
Antiproliferative activity
Issue Date: Jun-2012
Publisher: SOC CHILENA QUIMICA, CASILLA 2613, CONCEPCION, 00000, CHILE
Citation: JOURNAL OF THE CHILEAN CHEMICAL SOCIETY Volume: 57 Issue: 2 Pages: 1126-1129
Abstract: We report the preparation of a series of indolylquinone and pyridine derivatives in order to evaluate structure-activity relationships in human gastric (AGS), lung (SK-MES-1), bladder (J82) cancer cell lines and human normal lung fibroblasts (MCR-5). Two correlations tendency between half-wave redox potentials against their antineoplasic activity were found making it possible to establish that for epithelial human gastric cancer (AGS) cell lines and human normal lung fibroblasts (MCR-5). The quinone bioreduction should correspond to a one electron process under normomix conditions, whilst for all other lines this process should correspond to a two electron attachment via a hypoxic process.
Description: Theoduloz, C (Theoduloz, C.). Univ Talca, Fac Ciencias Salud, Talca, Chile
URI: http://dspace.utalca.cl/handle/1950/9117
ISSN: 0717-9324
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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