DSpace About DSpace Software
 

DSpace Biblioteca Universidad de Talca (v1.5.2) >
Dirección de Investigación >
Artículos en publicaciones ISI - Universidad de Talca >

Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/9156

Title: Antimicrobial phenylpropanoids from the Argentinean highland plant Parastrephia lucida (Meyen) Cabrera
Authors: D'Almeida, R.E.
Alberto, M.R.
Quispe, C.
Schmeda-Hirschmann, G.
Isla, M.I.
Keywords: Parastrephia lucida
Asteraceae
Antimicrobial activity
Phenylpropanoids
Issue Date: Jul-2012
Publisher: ELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
Citation: JOURNAL OF ETHNOPHARMACOLOGY Volume: 142 Issue: 2 Pages: 407-414
Abstract: Ethnopharmacological relevance: The Argentinean highland plant Parastrephia lucida (Meyen) Cabrera is used in traditional medicine as an antiseptic and anti-inflammatory crude drug. Aim of the study: To relate the antimicrobial effect of the crude drug with the constituents of the active fractions and traditional use. Materials and methods: Assay-guided isolation of the methanol (MeOH) plant extract was carried out using bacteria and yeasts as target organisms. Both ATCC and local strains were included in the study. The antimicrobial fractions and compounds were detected by bioautographic assays. Minimum inhibitory concentrations (MIC) of each extract and fraction were determined and compared with reference antibiotics. Fractions were analyzed by HPLC-DAD, GC-MS, H-1 NMR and C-13 NMR. Results: From the MeOH extract of the plant, assay-guided isolation of the antimicrobial constituents led to 12 phenylpropanoids and two simple phenolics. Most of the compounds occurring in the active fractions were E-caffeoyl or E-cinnamoyl esters including prenyl and phenethyl derivatives. The MIC values of the most active fractions ranged between 12.5 and 200 mu g/mL against reference strains and local isolates of Staphylococcus aureus and Enterococcus faecalis. Conclusions: The antimicrobial effect found in the crude drug was associated with mixtures of phenylpropanoids, including prenyl and phenethyl esters of caffeic and cinnamic acids. The results support at least in part the traditional use of the plant as local antiseptic. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Description: Quispe, C (Quispe, Cristina); Schmeda-Hirschmann, G (Schmeda-Hirschmann, Guillermo). Univ Talca, Inst Quim Recursos Nat, Talca, Chile
URI: http://dspace.utalca.cl/handle/1950/9156
ISSN: 0378-8741
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

Files in This Item:

File Description SizeFormat
TEXTO_COMPLETO.htmlACCESO RESTRINGIDO RED UTALCA3 kBHTMLView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2009  The DSpace Foundation - Feedback