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| Title: | Medicinal Plants of Chile: Evaluation of their Anti-Trypanosoma cruzi Activity |
| Authors: | Munoz, O.M.
Maya, J.D.
Ferreira, J.
Christen, P.
San Martin, J.
Lopez-Munoz, R.
Morello, A.
Kemmerling, U. |
| Keywords: | Anti-Trypanosoma cruzi
Drimenol
Isodrimenin |
| Issue Date: | 2013 |
| Publisher: | VERLAG Z NATURFORSCH, POSTFACH 2645, 72016 TUBINGEN, GERMANY |
| Citation: | ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES Volume: 68 Issue: 5-6 Pages: 198-202 |
| Abstract: | The extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity. Most active extracts were those obtained from Podanthus ovatifolius, Berberis microphylla, Kageneckia oblonga, and Drimys winteri. The active extract of Drimys winteri (IC50 51.2 mu g/mL) was purified and three drimane sesquiterpenes were obtained: polygodial, drimenol, and isodrimenin. Isodrimenin and drimenol were found to be active against the trypomastigote form of T cruzi with IC50 values of 27.9 and 25.1 mu M, respectively |
| Description: | San Martin, J (San Martin, Jose). Univ Talca, Inst Biol Vegetal & Biotecnol, Talca, Chile |
| URI: | http://dspace.utalca.cl/handle/1950/9442 |
| ISSN: | 0939-5075 |
| Appears in Collections: | Artículos en publicaciones ISI - Universidad de Talca
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