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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/9454

Title: Stereoselective bioreduction of beta-carboline imines through cell-free extracts from earthworms (Eisenia foetida)
Authors: Mirabal-Gallardo, Y.
Soriano, M.D.C.
Santos, L.S.
Issue Date: Apr-2013
Citation: TETRAHEDRON-ASYMMETRY Volume: 24 Issue: 8 Pages: 440-443 DOI: 10.1016/j.tetasy.2013.03.003
Abstract: Although remarkable advances have been made over the last decade in organic synthesis, catalysis, and biotechnology, there is still a need to introduce and develop new processes for chemical production to achieve sustainable and cleaner approaches to support the increasing global pharmaceutical/chemical industry. There is a growing need to produce optically active compounds in high yields to maintain and support areas such as pharmaceutical and natural product synthesis. Thus, chemists today are looking for alternative reactions carried out under green conditions. In this context, we describe beta-carboline imine reductions employing cell-free extracts from red Californian earthworms (Eisenia foetida) in high yields and enantiomeric excesses. The enantiomeric excess values of the bioreduction showed no dependence on the imine 1a-g substituents to afford amines with an (R)-configuration. Based on these data, a model for the cell-free extract from the earthworm is proposed. (C) 2013 Elsevier Ltd. All rights reserved.
Description: Mirabal-Gallardo, Y (Mirabal-Gallardo, Yaneris); Soriano, MDC (Soriano, Maria del Pilar C.) ; Santos, LS (Santos, Leonardo S.). Univ. Talca, Lab Asymmetr Synth, Chem Inst Nat Resources, POB 747, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/9454
ISSN: 0957-4166
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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