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Please use this identifier to cite or link to this item: http://dspace.utalca.cl/handle/1950/9460

Title: Annulation of substituted anthracene-9,10-diones yields promising selectively antiproliferative compounds
Authors: Castro-Castillo, V.
Suarez-Rozas, C.
Theoduloz, C
Cassels, B.K.
Castro-Loiza, N.
Keywords: Anthracene-9,10-diones
Synthetic oxoisoaporphines
Antiproliferative activity
Issue Date: Apr-2013
Citation: Source: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 62 Pages: 688-692 DOI: 10.1016/j.ejmech.2013.01.049
Abstract: Anthraquinone derivatives are well-known antiproliferative compounds, and some are currently used in cancer chemotherapy. Some families of annulated anthraquinone analogs have also been examined for antiproliferative activity, but in this regard almost nothing is known of 1-azabenzanthrones (7H-dibenzo [de,h]quinolin-7-ones). A series of 1-azabenzanthrone derivatives, their 2,3-dihydro analogs, and congruently substituted 9,10-anthracenediones were tested against normal human fibroblasts and four human cancer cell lines. Most of the heterocyclic compounds proved to be weakly to moderately antiproliferative with 1050 values extending down to 0.86 mu M, and exhibited up to 30-fold selectivity between cancer and normal cells. Both 1-azabenzanthrones and 1-aza-2,3-dihydrobenzanthrones were more potent than their anthraquinone counterparts, and almost without exception, the 2,3-dihydro compounds were more potent than the fully aromatic 1-azabenzanthrones. (C) 2013 Elsevier Masson SAS. All rights reserved.
Description: Theoduloz, C (Theoduloz, Cristina)[ 3 ]. Univ Talca, Fac Hlth Sci, Cell Culture Lab, Talca, Chile.
URI: http://dspace.utalca.cl/handle/1950/9460
ISSN: 0223-5234
Appears in Collections:Artículos en publicaciones ISI - Universidad de Talca

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